obesity
Conditions
Interventions
plant-based calorie restriction diet group:Participants in the plant-based calorie diet group will follow a "5+2" pattern, where they will adhere to the meal plan of Miouxian's "Weight Management" mea
calorie restriction group:The calorie-restricted diet involves reducing the total energy intake by 500 to 1000 kcal per day based on the target energy intake, or reducing the total energy intake by 1/
Sponsors
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, China
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Male and premenopausal female participants aged 18-45 years old are eligible to sign the informed consent form. 2. Participants diagnosed as obese based on a body mass index (BMI) ranging from 28 to 40 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Diagnosis of type 1 or type 2 diabetes, gestational diabetes, and some specific types of diabetes 2. Taking medications affecting weight or energy intake/energy expenditure in the last 3 months, including weight loss medications, antipsychotic drugs and glucocorticoids. 3. Underwent weight-loss surgery in the last 6 months 4. Currently participating in weight loss programs or weight change in the past 3 months (> 5% current body weight) 5. Serious liver dysfunction or chronic kidney disease (AST or ALT > 3 times the upper limit of normal, or eGFR6.0 as measured at screening) 12. Patients who took antibiotics or probiotics in the past 1 months 13. Patients who abused drugs or alcohol or suffered from severe mental disorder (major depression, schizophrenia, bipolar disorder) 14.Patients who are unwilling or unable to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastrointestinal flora;Biochemical test; | — |
Countries
China
Contacts
Public ContactLe Bu
the Tenth People's Hospital of Tongji University
Outcome results
None listed