acute pancreatitis
Conditions
Interventions
JPTF treatment group:JPTF granule oral/nasal feed, once every 6 hours
placebo control group:placebo granule oral/nasal feed, once every 6 hours
Sponsors
Jinjiang Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 80 years (2) Meets the diagnostic criteria for "Acute Pancreatitis" (3) Meets the "predicted Severe Acute Pancreatitis" diagnostic criteria (APACHE II score = 8, or Imrie score = 3 , or CRP>150mg/L) (4) Meets the diagnostic criteria for "spleen deficiency and fu-organ excess" in TCM (5) Admission within 72 hours after onset of Acute Pancreatitis (6) Expected hospitalization time exceeds 7 days (7) Informed consent
Exclusion criteria
Exclusion criteria: (1) Pregnant pancreatitis (2) Severe respiratory failure, severe systemic circulatory failure, coma, or other dangerous symptoms that are difficult to reverse, with an estimated survival time of less than 7 days (3) Patients with deteriorating hemodynamic status who require an increase in the dosage of vasoactive drugs (under comprehensive fluid resuscitation and treatment with 2ug/kg · min or higher doses of norepinephrine, systolic blood pressure<90mmHg, arterial blood pH<7.0) (4) Individuals with known severe cardiovascular, respiratory, renal, liver, and blood system diseases, as well as severe immune dysfunction, malignant tumors, epilepsy, and other diseases (5) Long term use of hormones or immunosuppressive drugs (6) Individuals equipped with a pacemaker or defibrillator (7) The clinical situation of significant intestinal ischemia or obstruction, severe abdominal distension or compartment syndrome, active gastrointestinal bleeding, and high-level gastrointestinal fistula without satisfactory placement of enteral nutrition tubes affecting the treatment of traditional Chinese medicine and enteral nutrition through the gastrointestinal tract (8) Allergic to TCM formula or enteral nutrition (9) Undergone other clinical trials within 6 months prior to the start of the trial (10) Participated in this trial before
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D5`s compliance rate of enteral nutrition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Enteral nutrition tolerance score;Acute Gastrointestinal Injury Ultrasonography Score;Acute Gastrointestinal Injury grade;Gastrointestinal Dysfunction Score;all-cause mortality;Length of stay in ICU;Length of stay in hospital;Sequential Organ Failure Assessment Score; Acute Physiology and Chronic Health Evaluation II Score;Euroqol 5-dimension 5-level questionnaire(EQ-5D-5L) Score; | — |
Countries
china
Contacts
Public ContactChen Mingzhi
Jinjiang Hospital of Traditional Chinese Medicine
Outcome results
None listed