Coranary heart disease
Conditions
Interventions
Case series:None
Sponsors
Jinhua Hospital Affiliated to Zhejiang University School of Medicine (Jinhua Municipal Central Hospital)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) The clinical diagnoses that meet the criteria for coronary heart disease include asymptomatic myocardial ischemia, occult coronary heart disease, angina, myocardial infarction, and ischemic heart failure. Patients who are first diagnosed with coronary heart disease and require lipid-lowering treatment (2) are not limited to age, gender, or height. (3) Agree and sign the patient's informed consent form (4) taking atorvastatin as the only lipid-lowering medication
Exclusion criteria
Exclusion criteria: (1) Excluding pregnant or lactating women (2) patients with moderate to severe liver disease (child pugh score B or C), (3) tumor patients and patients with mental disorders (4) patients who need to take other lipid-lowering drugs in the two weeks before and during the trial period (4) medication instructions clearly state drugs that affect atorvastatin metabolism (cyclosporine, erythromycin, gefeflozil, colesemide), (5) hyperlipidemia caused by concomitant drugs (6) ALT/AST values persist>3 times, accompanied by muscle symptoms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ABCB1 (rs1045642, rs1128503, rs2032582, rs2373588);SLCO1B1 (rs2306283);Blood lipid levels, liver function, creatine kinase before and after treatment;ABCG2 (rs2231142); | — |
Secondary
| Measure | Time frame |
|---|---|
| The concentration of atorvastatin and 2-OH atorvastatin; | — |
Countries
China
Contacts
Public ContactZhaowei Zhang
Jinhua Hospital Affiliated to Zhejiang University School of Medicine (Jinhua Municipal Central Hospital)
Outcome results
None listed