dry eye disease, meibomian gland dysfunction, demodex blepharitis
Conditions
Interventions
Patients with both cylindrical dandruff at the base of the eyelashes and meibomian gland uneven atrophy :None
Patients only with cylindrical dandruff at the base of the eyelashes:None
Patients only with meibomian gland uneven atrophy:None
Patients with neither cylindrical dandruff at the base of the eyelashes nor meibomian gland uneven atrophy:None
Sponsors
Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 18~75 years old patients with dry eye
Exclusion criteria
Exclusion criteria: 1. Previous surgical history of chalazion; 2. Previous history of eyelid surgery; 3. History of dry eye laser treatment in the past 6 months; 4, chronic eye disease patients with long-term point use of eye drops (except for patients with simple dry eye disease) : such as glaucoma, allergic conjunctivitis, viral keratitis; 5. Patients with mental illness, cognitive dysfunction, cardiovascular and cerebrovascular accidents, malignant arrhythmias, and dysfunction of important organs; 6. Systemic connective tissue diseases and serious autoimmune diseases, such as rheumatoid arthritis, sarcoidosis, lupus erythematosus, thyroiditis, etc.; 7, the whole body and eye surgery history, trauma history or other diseases need long-term use of eye drops. 8. Since the uneven atrophy of meibomian glands could not appear when the atrophy of meibomian glands was severe, the glandular data of meibomian glands were all close to 0, so patients with atrophy of meibomian glands greater than 3/4 were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eyelash demodex examination with microscope;Meibomian gland photography;eyelash follicle demodex examination with confocal microscope; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ocular Surface Disease Index(OSDI) ;cornea fluorescein score( CFS);fluorescein breakup time (FBUT);tear secretion experiment;Eyelid lipid assessment;Meibomian gland expression score;conjunctival abnormalities; | — |
Countries
China
Contacts
Public ContactFu Yana
Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University
Outcome results
None listed