Programmed intermittent bolus versus continuous peripheral nerve blockade for postoperative analgesia after total knee arthroplasty: a randomized controlled trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400081291

Enrollment

Unknown

Registered

2024-02-28

Start date

2023-07-20

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Articular bone of knee, unspecified

Interventions

CPNB group:The PIB group is set with a background volume given under continuous peripheral nerve blockade mode.

PIB group:The PIB group is set with a background volume given under programmed intermittent bolus mode.

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: ASAI~III undergo total knee arthroplasty between 60 year old and 80 year old accepted femoral nerve block signature on the Informed consent form

Exclusion criteria

Exclusion criteria: be allergic to anesthetics with a history of drug abuse Infection around the puncture site Unilateral neuromuscular disease/injury and knee joint revision Moderate anemia (Hb<90g/L) Severe kidney disease (GFR<50 ml/min) Severe liver disease (Child Pugh B or C grade) History of myocardial infarction, heart failure and Respiratory failure Cognitive disease

Design outcomes

Primary

Measure	Time frame
Consumption rate of Ropivacaine;	—

Secondary

Measure	Time frame
VAS score;supplementary analgesic drugs;efficiency of patient-controlled analgesia;satisfaction of patient ;QOR-15;total consumption volume of Ropivacaine;	—

Countries

China

Contacts

Public ContactXia Feng

The First Affiliated Hospital of Sun Yat-sen University

fengxia@mail.sysu.edu.cn+86 136 8887 7856

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026