Depression
Conditions
Interventions
Intervention group:Prescribed probiotics were taken daily for eight weeks.
placebo:Placebo was administered daily for eight weeks
Sponsors
The Second People's Hospital of Lishui
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1)Age: >18 years; (2)Have received formal education =6 years; (3)Patients with moderate to severe depressive disorder were diagnosed according to the ICD-10 diagnostic criteria(F32.1F32.2F32.3F33.1F33.2F33.3), Hamilton Depression Scale > 17; (4)Newly hospitalized patients in the Second People's Hospital of Lishui(Time of admission < 2weeks); (5)Signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1)Had psychotic symptoms such as hallucinations and delusions, and had serious suicidal tendencies; (2)History of alcohol and substance abuse; (3)Systemic use of antibiotics or antifungal agents within 30 days before the study; (4)History of severe food allergy, including cow's milk allergy; (5)Pregnant and lactating women; (6)Other serious medical conditions (uncontrolled diabetes, uncontrolled hypertension, hyperlipidemia, obesity BMI> 25, cardiovascular disease with antiplatelet or anticoagulant therapy, severe gastrointestinal diseases such as Crohn's disease and ulcerative colitis); (7)Use of probiotic products within six months; (8)Inability to comply with study requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptoms of depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-reported psychological attributes;Biomarkers; | — |
Countries
China
Contacts
Public ContactKe Zhao
The Second People's Hospital of Lishui
Outcome results
None listed