Key technology and application research on malignant risk identification and early diagnosis of pulmonary nodules based on VOCs in exhaled breath using "gas phase biopsy"

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400081283

Enrollment

Unknown

Registered

2024-02-28

Start date

2024-04-01

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary nodules

Interventions

Lung nodule group:NA

Healthy control group:NA

Eligibility

Sex/Gender

All

Age

45 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for the pulmonary nodule group: 1) age =45 years old; 2) nodules in the lungs on imaging examination; 3) no signs of worsening of the lesions after 1 year or more of follow-up. Inclusion criteria for healthy controls: 1) age =45years old; 2) no abnormal findings in imaging examinations; 3) no respiratory disease or symptoms such as cough and sputum.

Exclusion criteria

Exclusion criteria: 1) Suffering from benign lung diseases such as pulmonary infection, emphysema; 2) History of malignant tumors within 5 years; 3) Patients have the following metabolic diseases: bronchial asthma, diabetes, severe liver function damage, end-stage renal disease and acute stage of inflammation; 4) No informed consent was signed.

Design outcomes

Primary

Measure	Time frame
Pulmonary function;Risk factors of pulmonary nodule;The malignancy of pulmonary nodules;	—

Secondary

Measure	Time frame
Volatile organic compounds in exhaled breath;	—

Countries

China

Contacts

Public ContactWeijuan Gong

Yangzhou University

wjgong@yzu.edu.cn+86 139 5279 0810

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026