Patients undergoing laparoscopic gynecological surgery
Conditions
Interventions
Opioid-free anesthesia group (OFA group):Anesthesia induction and maintenance with opioid-free drugs
Opioid anesthesia group (OA group):Anesthesia induction and maintenance with opioid drugs
Sponsors
Fujian Medical University Affiliated Union Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Female patients undergoing elective laparoscopic gynecological surgery (including hysterectomy, myomectomy, oophorectomy, salpingectomy, cystectomy); (2) 18-65 years old; (3) Body mass index (BMI) 18.5-29.9 kg/m²; (4) Preoperative ASA grade I-?; (5) Normal liver and kidney function; (6) Mentally normal, can correctly understand the numerical rating scale (NRS) score, assess the degree of pain; (7) Patients informed consent.
Exclusion criteria
Exclusion criteria: ( 1 ) Patients with a history of asthma, diabetes, brain diseases ( such as epilepsy, increased intracranial pressure, brain tumors, previous cerebral infarction, cerebral hemorrhage, etc. ) and a history of major surgery ; ( 2 ) Patients with sinus bradycardia, atrioventricular and intraventricular or sinoatrial block, ventricular premature beats, atrial fibrillation, supraventricular or ventricular tachycardia, unstable angina, valvular disease and previous myocardial infarction and poorly controlled hypertension ; ( 3 ) pregnant or lactating women ; ( 4 ) Patients with abnormal coagulation function ; ( 5 ) patients with previous gastrointestinal bleeding or gastroduodenal ulcer ; ( 6 ) Patients with drug allergy and nerve block contraindications involved in the trial ; ( 7 ) patients with chronic pain or long-term use of sedatives or analgesics ; ( 8 ) Patients with glaucoma, long-term use of ß-blockers and heart rate less than 50 beats / min.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PONV;post-operational pain;Postoperative gastrointestinal function recovery time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay sedation score;recovery time;The first time of get out of bed after operation;hospital stay after operation;Drug use before induction and during operation;Postoperative analgesic and antiemetic consumption;The first postoperative analgesia time;Retention time in resuscitation room; heart rate; systolic blood pressure;diastolic blood pressure,;mean arterial pressure ;postoperative adverse reaction; | — |
Countries
China
Contacts
Public ContactLin Pengtao
Fujian Medical University Affiliated Union Hospital
Outcome results
None listed