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Rehabilitation efficacy of sound startle response combined with conventional speech training in patients with post-stroke dysarthria and related neural mechanisms

Rehabilitation efficacy of sound startle response combined with conventional speech training in patients with post-stroke dysarthria and related neural mechanisms

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081279
Enrollment
Unknown
Registered
2024-02-28
Start date
2024-05-01
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke dysarthria

Interventions

Control group:Pseudo-ASP-articulation task (10min) + conventional dysarthria rehabilitation training
Experimental group:ASP - articulation task (10min) + regular dysarthria rehabilitation training

Sponsors

Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Age from 18 to 80 years old, male or female; 2. Patients who met the diagnostic criteria of stroke (first stroke confirmed by clinical CT or MRI) were conscious, with stable vital signs, and the course of stroke was from 2 weeks to 6 months. 3. Mild to moderate dysarthria was assessed by Frenchay rating scale. 4. Native speaker of Chinese, can communicate in putonghua in daily life before onset, primary school or above diploma 5. No history of hearing impairment and good tolerance to sudden sound stimulation at 114 dB. 6. Sign the informed consent, voluntarily participate in the trial, and be able to complete the trial. 7. The head was intact and no craniotomy and/or skull repair was performed.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1. The subjects were pregnant, dizzy, poor mental state, epileptic seizures, psychiatric history, and/or complicated with serious cardiovascular, liver and kidney diseases within the past year. 2. A history of other conditions affecting swallowing, speech and/or language, such as dementia, Parkinson's disease or oral cancer; 3. Patients below grade 3 on the BDAE aphasia severity assessment. 4. Patients with severe cognitive impairment assessed by MMSE (MMSE score < 20) 5. Patients with vocal cord paralysis, hearing impairment, and visual impairment were excluded. 6. Exclude those with damage or lesions in organs or muscles involved in articulation. 7. Patients with upper respiratory tract infection, such as cough, hoarseness and other patients who affect voice, were excluded. 8. Patients with skull defects, such as those who underwent surgical treatment such as decompressive craniectomy after stroke, were excluded.

Design outcomes

Primary

MeasureTime frame
Clinical Scale evaluation;

Secondary

MeasureTime frame
Analysis of acoustic properties;Functional near-infrared spectroscopy;

Countries

China

Contacts

Public ContactLu Min

Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology

lumin@hust.edu.cn+86 139 7126 8939

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026