Peripheral nerve toxicity caused by oxaliplatin chemotherapy
Conditions
Interventions
control group:Use of evidence-based nursing programs: systematic evaluation before chemotherapy, CIPN management, health education
Experimental group A:On the basis of evidence-based nursing scheme, the combination of Wenjing Tongluo prescription and traditional Chinese medicine fumigation
Experimental group B:The limbs moxibustion method was combined with thunder fire moxibustion on the basis of evidence-based nursing scheme
Experimental group C:Experimental group A and experimental group B were combined
Sponsors
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: ? Patients diagnosed by histopathology and/or cytology as gastrointestinal malignancies; ? Did not receive any chemotherapy regimen before, and received oxaliplatin chemotherapy regimen for the first time; ? Age 18-75 years old, gender is not limited; (4) Predicted survival of more than 6 months and completion of at least 6 chemotherapy regimens; ?Karnofsky scores more than 60 points. Patients who meet all of these criteria are eligible for inclusion.
Exclusion criteria
Exclusion criteria: ? A history of neuropathy; ? Patients with previous peripheral nerve function lesions (such as diabetes, cerebrovascular disease, peripheral nerve function lesions caused by trauma); (3) Patients with spinal cord compression syndrome, spinal canal stenosis or spinal nerve root compression, central nervous system tumor, Raynaud's syndrome, severe cardiovascular and cerebrovascular diseases, hepatic and renal insufficiency before chemotherapy without surgical treatment; (4) Pregnant, lactating women or mental abnormalities and do not cooperate with treatment; Are receiving other medications or radiation therapy that may cause peripheral nerve toxicity. The presence of hand and foot skin lesions (such as eczema) or a history of drug contact allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of acute peripheral nerve toxicity;Comprehensive Assessment Scalefor Chemotherapy-Induced Peripheral Neuropathy in Survivors of Cancer; | — |
Secondary
| Measure | Time frame |
|---|---|
| EORTC QLQ-C30;Pittsburgh Sleep QualityIndex; | — |
Countries
China
Contacts
Public ContactAlice.wang
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed