hip and knee joint disease
Conditions
Interventions
The olanzapine group A:Olanzapine 2.5mg qn was taken orally from the day before surgery for a total of 5 days during the perioperative period and stopped on the day of discharge
Control group B:There was no intervention on emotion and sleep during perioperative period
Group C:No intervention, as a prospective observation cohort of patients in Group B (without anxiety)
Sponsors
Department of Orthopaedic surgery, West China Hospital, Sichuan University.
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients between 18 and 80 years were scheduled to undergo THA/TKA for end-stage hip/knee disease and had abnormal STAI scores before surgery or significant anxiety symptoms.
Exclusion criteria
Exclusion criteria: ? The patient could not swallow pills, be taking antipsychotics, or have a diagnosed psychiatric disorder. ? Preoperative ECG correction of QT interval greater than 450ms, or a history of tip torsion; Patients with past, myocardial infarction or unstable angina, arrhythmia, congestive heart failure, recent postural hypotension or vasovagal syncope, or perioperative hypotension (systolic blood pressure less than 90 mm Hg). ? Patients with olanzapine contraindications, including known drug allergy, Parkinson's disease, or Lewy body dementia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| State-Trait Anxiety Inventory-State score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale-Pain score;Visual analogue scale-Sleep disorder score;Visual analogue scale-Nausea;Incidence of postoperative vomiting;Harris Hip Score and Hospital for Special Surgery Knee Score;Length of stay;Incidence of postoperative complications;Patient satisfaction;Drug-related adverse reactions; | — |
Countries
China
Contacts
Public ContactZongke Zhou
Department of Orthopaedic surgery, West China Hospital, Sichuan University.
Outcome results
None listed