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Esketamine on tourniquet-induced hypertension in patients undergoing below-knee orthopedic surgery and general anesthesia: A randomized double-blind controlled trial

Esketamine on tourniquet-induced hypertension in patients undergoing below-knee orthopedic surgery and general anesthesia: A randomized double-blind controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081237
Enrollment
Unknown
Registered
2024-02-27
Start date
2024-02-28
Completion date
Unknown
Last updated
2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tourniquet-induced hypertension

Interventions

Sponsors

Department of Anesthesiology, First Affiliated Hospital of Soochow University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Aged 18-70 years; ASA I to III; undergoing elective below-knee orthopedic surgery with tourniquet under general anesthesia .

Exclusion criteria

Exclusion criteria: Ischemic heart disease, severe cardiac, liver or renal insufficiency; uncontrolled hypertension; long-term use of opioids, sedatives, or antidepressants; history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis; puncture site infection, allergy to local anesthetics, and tourniquet contraindications; tourniquet use time 150min; inability to communicate or refusal to participate in research.

Design outcomes

Primary

MeasureTime frame
Incidence of tourniquet-induced hypertension;

Secondary

MeasureTime frame
Hemodynamic data;Incidence of hypotension;Intraoperative dosage of opioids, total amount of antihypertensive drugs such as esmolol, nicardipine and nitroglycerin;Postoperative nausea and vomiting, dizziness, adverse mental reactions;NRS scores at 1, 6, 12, 48 hours after surgery;Postoperative analgesic use;Postoperative hospital stay;

Countries

China

Contacts

Public ContactPeng Ke

Department of Anesthesiology, First Affiliated Hospital of Soochow University

pengke@suda.edu.cn+86 159 6215 5989

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026