A randomized controlled trial of acupuncture combined with cognitive training in the treatment of mild to moderate Alzheimer's disease

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400081221

Enrollment

Unknown

Registered

2024-02-26

Start date

2023-05-29

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer dementia

Interventions

cognitive training group:cognitive training

acupuncture + cognitive training group:Combined Acupuncture and Cognitive Training

Sham acupuncture + cognitive training group:Sham acupuncture combined with cognitive training

Eligibility

Sex/Gender

All

Age

50 Years to 85 Years

Inclusion criteria

Inclusion criteria: ?Conform to the probable AD standard in the NIA-AA standard; ? 50 years old = age = 85 years old; ? 0.5 points = clinical dementia assessment score = 2 points; ? Hachinski ischemia scale score = 4 points; ? Sign the informed consent and voluntarily participate in this experiment; ? If the subject himself has the ability to make decisions, the informed consent shall be signed by himself; if the patient's education level is low and unable to sign the informed consent, the legal guardian shall sign the informed consent; ?The caregiver or family member (guaranteed to accompany the patient =3 hours a day, =3 days a week) signed the informed consent. ? Able to follow instructions, without any hearing or visual impairment, and without physical dysfunction.

Exclusion criteria

Exclusion criteria: ?With severe cerebrovascular disease; ?With other diseases that can cause cognitive dysfunction or progressive memory impairment; ? Drug-induced cognitive dysfunction or progressive memory impairment; ?Patients with severe cardiovascular disease, malignant tumor, severe liver and kidney insufficiency; ?Patients with severe fear of needles, fainting of needles, and severe skin infection; ?Patients who are highly dependent on nursing facilities; ?Patients who have received acupuncture treatment and cognitive training in the last 2 weeks; ? Participating in other clinical trials at the time of enrollment.

Design outcomes

Primary

Measure	Time frame
Alzheimer disease assessment scale cognition, ADAS-Cog;Mini-mental State Examination, MMSE;Activities of Daily Living, ADL;Neuropsychiatric Inventory, NPI;Clinician Interview–Based Impression of Change scale, CIBIC;Zarit Caregiver Burden Interview, ZBI;Treatment Satisfaction Survey, TSS;	—

Countries

China

Contacts

Public ContactJia Baohui

Guang'anmen Hospital of China Academy of Chinese Medical Sciences

myrroossee@aliyun.com+86 150 2009 0050

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026