Chloasma
Conditions
Interventions
Experimental group:During the trial, the tested part must use the test products provided by the testing organization, and can not use any other skin care products or medicines that have the effect of
Subjects should not be exposed to the sun during the experiment, and should do a good job in the test site of the sun protection.
Control Group:During the trial, the test site must use the control product provided by the test organization, and can not use any other skin care products or drugs that have the effect of freckle whit
Sponsors
Cosmetics Testing Center, Dermatology Hospital of Southern Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. From 18 to 50 years old, healthy female or male; 2. The test site has at least one obvious color spot with an ITA difference greater than 10 from the surrounding skin, and the diameter is not less than 3mm (it cannot be freckles, pigmented nevus, etc. that are difficult to improve with topical preparations); 3. Consciously skin sensitivity, positive lactic acid tingling test (3 points); 4. No allergic diseases, no allergic history of cosmetics and other topical preparations; 5. There is no history of light susceptibility disease, and no drugs affecting light susceptibility in the recent future; 6. The skin of the test site should not have birthmark, inflammation, scar, hairy and other phenomena; 7. Ability to understand the trial process, voluntarily participate in the trial and sign a written informed consent;
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women, or those with recent pregnancy planning; 2. Patients with a history of skin diseases such as psoriasis, eczema, ectopic dermatitis, and severe acne; or other chronic systemic diseases; 3. Patients with oral or topical anti-inflammatory drugs in the past one month; 4. Those who have used fruit acid, salicylic acid and other products or drugs that affect skin color (such as hydroquinone preparations) in the past 2 months; 5. Those who have used retinoids or have been treated with chemical stripping, laser and pulse light in the test site in the past 3 months; 6. Those who are inevitably exposed to sunlight for a long time; 7. Have participated in other clinical trials in the past 2 months; 8. Those deemed unsuitable to participate by other clinical assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The measurement of skin tone;The measurement of skin melanin;Facial image uptake and analysis;The visual assessment of investigator;Self-assessment of subject; | — |
Secondary
| Measure | Time frame |
|---|---|
| The measurement of transepidermal water loss;The measurement of stratum corneum;MELASQOL;mMASI; | — |
Countries
China
Contacts
Public ContactYe Li
Dermatology Hospital of Southern Medical University
Outcome results
None listed