cerebrovascular disease
Conditions
Interventions
inventory group:Evolocumab 420mg q4w subcutaneous injection combined with statin (atorvastatin 20mg) treatment
control group:Statin therapy (atorvastatin 20mg)
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Sign the informed consent form 2) 80 years old = patient age = 18 years old 3) For patients diagnosed with non-cardiogenic ischemic stroke/transient ischemic attack, the time of stroke is <14 days from enrollment. Patients diagnosed with ischemic stroke by head CT or magnetic resonance imaging (MRI) 4) Brain MRA/CTA/DSA confirms severe intracranial artery stenosis (70%-99%) 5) hematology test ?20000/mm3=white blood cell count=4000/mm3 ?Neutrophils =1500/mm3 ?Platelet count =100000/mm3 ?Hemoglobin =110g/L ?Normal range of coagulation function 6) laboratory examination ?Total bilirubin, AST, ALT=1.0X the upper limit of normal values ?Creatinine clearance 80~120ml/min ?Urine microprotein is normal
Exclusion criteria
Exclusion criteria: 1) Previous history of hemorrhagic stroke; 2) Have a history of kidney disease; 3) Have a history of heart failure; 4) Have a history of malignant tumors in the past 10 years; 5) The patient also suffers from other uncontrolled serious diseases, such as severe infection, arrhythmia, congestive heart failure diabetes, severe mental and behavioral abnormalities, etc.; 6) Patients with obvious intracranial hypertension and midline shift requiring emergency surgery; 7) History of gastrointestinal ulcer and gastrointestinal bleeding; 8) Patients with a history of allergies or adverse reactions to trial drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atherosclerotic plaque morphological assessment; | — |
Countries
China
Contacts
Public ContactLei He
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed