HIV complicated with tumor
Conditions
Interventions
queue A:None
Sponsors
Shanghai Public Health Clinical Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Participants who visited Shanghai Public Health Clinical Center and other hospitals from January 1, 2015 to June 17, 2023 were included: Queue a 1) It conforms to the diagnostic criteria of AIDS in AIDS phase in China Guidelines for AIDS Diagnosis and Treatment (2021 Edition), and the subjects must agree to receive antiretroviral treatment when they are included in the study; 2) Age above 18 (inclusive); 3) All patients must be pathologically diagnosed with advanced tumors (locally advanced or metastatic) before entering the group, including but not limited to: lung cancer, head and neck cancer, cervical cancer, melanoma, anal cancer, pancreatic cancer, gastroesophageal cancer, triple negative breast cancer, bladder cancer, cholangiocarcinoma, Kaposi's sarcoma, lymphoma, ovarian cancer, Merkel cell cancer and any other tumor types whose immune checkpoint inhibitors have shown anti-tumor activity. 4) Agree to receive ICIs-based treatment when joining the group. Queue b Patients with HIV complicated with non-cell lung cancer in stage IV in cohort A were selected. According to this group of patients, the following variables were matched according to 1: 2: (1) age, (2) gender, (3)ICIs category, (4) use of concurrent chemotherapy (yes/no) and (5) times of systematic treatment before ICIS started, cohort B was selected.
Exclusion criteria
Exclusion criteria: 1) Participating in other interventional clinical studies; 2) Other untreated coexisting HIV-related malignant tumors;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective remission rate (ORR) of tumor;Progression-free survival (PFS);Overall survival (OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| HIV RNA viral load;Lymphocyte count; | — |
Countries
China
Contacts
Public ContactChen Jun
Shanghai Public Health Clinical Center
Outcome results
None listed