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Effect of different doses of ciprofol on hemodynamics induced by general anesthesia in elderly diabetic patients undergoing spinal surgery: a randomized controlled trial

Effect of different doses of ciprofol on hemodynamics induced by general anesthesia in elderly diabetic patients undergoing spinal surgery

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081164
Enrollment
Unknown
Registered
2024-02-26
Start date
2024-03-01
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lumbar disc herniation

Interventions

A group:General anesthesia was induced with 0.2mg/kg ciprofol
B group:General anesthesia was induced with 0.4mg/kg ciprofol
C group:General anesthesia was induced with 0.4mg/kg ciprofol

Sponsors

The second Hospital of Shanxi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Diabetic patients (all clearly diagnosed by secondary and above public hospitals); (2) Age =65 years old; (3) ASA grade II-III; (4) BMI: 18-30kg/m2, patients undergoing general anesthesia tracheal intubation lumbar PLIF.

Exclusion criteria

Exclusion criteria: Ciprofol allergy, abnormal liver and kidney function, bradycardia (heart rate less than 60 beats/min), hypotension (mean arterial pressure < 65mmhg), and prolonged QT interval were not able to cooperate with investigators.

Design outcomes

Primary

MeasureTime frame
Incidence of hypotension during anesthesia induction;

Secondary

MeasureTime frame
The area under the curve where the blood pressure was lower than the basal blood pressure at induction of anesthesia;Incidence of bradycardia;blood glucose level;

Countries

China

Contacts

Public ContactJiang Xiaorui

The Second Hospital of Shanxi Medical University

592451474@qq.com+86 186 3668 2046

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026