postoperative delirium
Conditions
Interventions
Group of multimodal brain function monitoring anesthesia management:Multi-modal Brain Function Monitoring(Sedation Index IoC1+ Injury Sensitivity Index IoC2 + Noninvasive Brain Oxygen Saturation rScO2
Group of single BIS monitoring anesthesia management:single Bispectral index monitoring
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Elderly patients (=65 years old) with diabetes 2.Scheduled to undergo off pump coronary artery bypass grafting under general anesthesia 3.ASA class II-IV, NYHA class II-III 4.Voluntarily agree to participate in this trial, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery 2. LVEF<40% 3. Recent history with acute cerebral stroke, severe cranial stenosis, mental illness, taking antipsychotic drugs, drug abuse, or alcohol abuse history 4. Visual or auditory impairments, preoperative MMSE score<23, positive POD screening 5. Coexisting severe chronic liver and kidney diseases 6. Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative complications :incidence of important organ complications(New onset arrhythmia, new onset acute myocardial infarction, heart failure, pulmonary infection, atelectasis, acute respiratory failure, acute stroke, acute kidney injury), wound infection rate, postoperative all-cause mortality rate;Postoperative recovery (Ventilator usage duration, ICU stay duration, and hospitalization duration);Serum test : Syndecan-1,IL-6,CRP/hs-CRP, Cortisol, S-100ß, NSE, BDNF,Tau protien, cTnI, cystatin C, NT-proBNP ,SCr, BUN; | — |
Countries
China
Contacts
Public ContactWang Tianlong
Xuanwu Hospital, Capital Medical University
Outcome results
None listed