Lower extremity ischemia reperfusion injury
Conditions
Interventions
Experimental group:Esketamine (initial dose 0.5mg/kg, maintenance dose 0.125mg/kg/h)
Control group:Saline (same syringe, same injection method and same injection speed)
Sponsors
Zhejiang Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients who underwent unilateral TKA surgery under combined spinal epidural anesthesia and needed to use a pneumatic tourniquet during the operation; 2. Elderly patients aged 60-90 years old; 3. The American Society of Anesthesiology was graded I-III;
Exclusion criteria
Exclusion criteria: 1. NYHA score = grade III; 2. Child Pugh score = grade B; 3. Chronic kidney disease = stage 3; 4. Severe chronic obstructive pulmonary disease and asthma; 5. SpO2 10×10^9/L) 8. Abnormal coagulation function; 9. BMI > 30kg/m^2; 10. Neurological and mental diseases; 11. Patients who were allergic to any experimental drugs; 12. Patients participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| flammatory mediator indicators (TNF-a, IL-6, and IL-8);Oxidative stress indicators (MDA, SOD, and CAT);Biochemical indicators related to functional organs (CK, LDH, AST, ALT, Cr, UA, Lac); | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs(HR, MAP, SAP, DAP, RR, ETCO2, and SpO2);hospital anxiety and depression scale, HAD;numerical rating scale, NRS;Peripheral diameter of thigh and ROM of knee joint before and after operation;Getting out of bed for the first time after operation;Dosage of patient-controlled intravenous analgesia;Postoperative complications;Continuous monitoring after operation;Diameter of optic nerve sheath; | — |
Countries
China
Contacts
Public ContactJun Du
Zhejiang Hospital
Outcome results
None listed