Prostate Cancer
Conditions
Interventions
Gold Standard:Pathological diagnosis results after prostate biopsy
Index test:cf-ROBUSTTM methylation library preparation method, Next generation sequencing (NGS), RNA-Seq
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
Male
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged = 18 years and 12 months, and an ECOG score of 0-2 points. 4.All samples should have corresponding basic clinical information, including sample ID number (outpatient number, medical record number, contact information and hospital number), gender, age, smoking history, chemical exposure history, family history of prostate cancer and clinical diagnosis information. 5.Control cases of other urinary tract diseases other than prostate cancer (which were eventually clinically diagnosed as non-prostate cancer), including prostatic hyperplasia, prostatitis, urinary tract stones, urinary tract infection, kidney cancer, bladder cancer, ureteral cancer, renal pelvis cancer, etc.
Exclusion criteria
Exclusion criteria: 1.Researchers determine patients with other serious illnesses that may affect follow-up and short-term survival, or any medical reasons that show significant risk of death during the 1-year study period. 2.Samples with missing information, such as sample numbers (outpatient numbers, medical record numbers or hospital numbers, etc.), gender, age, clinical diagnosis and others. 3.Samples that are not fresh or have insufficient sample size to complete all experiments. 4.Other situations deemed unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA Methylation;RNA expression;Sensitivity, SE;Specificity, SP;Accuracy;Positive predicative value, PPV, PV+;Negative predictive value, NPV,PV-; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive likelihood ratio;Negative likelihood ratio; | — |
Countries
China
Contacts
Public ContactLong Wang
Department of Urology, The Third Xiangya Hospital of Central South University
Outcome results
None listed