ST elevation myocardial ischemia post PCI
Conditions
Interventions
Verum acupuncture group:Verum acupuncture plus Standard therapy
Sham acupuncture group:Sham acupuncture plus Standard therapy
Healthy group:None
Sponsors
Affiliated Hospital of Chengdu University of traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients: 1. meets diagnostic criteria for STEMI: a.intense squeezd pain in the poststernal or precardiac area (usually more than 10-20 minutes) that radiates to the left upper arm, jaw, neck, back, or shoulder; Or accompanied by nausea, vomiting, sweating and dyspnea, some patients may have syncope. And these symptoms can not be reliefed by taking nitroglycerin; b.the ECG showed ST segment elevation in at least 2 limb leads with consecutive lead elevation =1mm, or ST segment elevation =2mm in two or more consecutive leads in the thoracic region; c.patients whose symptoms and ECG can definitively diagnose STEMI do not need to wait for myocardial injury markers or imaging results. It is recommended to routinely detect the level of cardiac markers in the acute stage and select troponin (cTnI), but reperfusion therapy should not be delayed because of this. The evolution of cardiac markers should be dynamically observed 2. receiving PCI within 12 hours of hospitalized; 3. be male or female, aged between 18 and 85 years; 4. volunteer to participate in this study and sign the informed consent. Healthy person: 1.18 years old = 85 years old, male or female; 2. Not suffering from organic or functional diseases; 3.No mental disorder; 4. No recent participation in other clinical trials; 5. Subjects voluntarily sign an informed consent form.
Exclusion criteria
Exclusion criteria: Patients: 1. combined with severe primary diseases such as digestive diseases, urinary diseases, respiratory diseases, blood diseases, nervous diseases and endocrine diseases which cannot be effectively controlled; 2. with severe complications post PCI, such as coronary artery occlusion, no reflow, coronary artery perforation, etc; 3. cardiac shock had occurred before randomization; 4. chest pain caused by heart valve disease, hypertrophic cardiomyopathy and dilated cardiomyopathy, non-cardiac diseases including severe neurosis,climacteric syndrome, cervical spondylosis, esophagus, lungs, or chest wall, etc. 5. with mental disorders and intellectual disabilities who could not cooperate with the questionnaire survey; 6. involvement in other researches. Healthy person: 1.Smokers and alcoholics; 2. Pregnant or lactating women; 3.Those who are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Troponin I; | — |
Secondary
| Measure | Time frame |
|---|---|
| CreatineKinase (CK);CreatineKinaseIsoenzyme (CK-MB);Lactate Dehydrogenase (LDH);C-reactive protein (CRP);IL - 10 ;IL – 1ß;TNF-a;Heart Rate Variability (HRV);Echocardiogram;VAS pain score for angina pectoris;6 minutes walk test;Cardiovascular adverse events;Chinese cardiovascular patients life quality;Zung self rating anxiety scale;Zung depression self rating scale;Serum exosomal miRNA; | — |
Countries
China
Contacts
Public ContactQianhua Zheng; Xie Wen
Chengdu University of Traditional Chinese Medicine; Affiliated Hospital of Chengdu University of traditional Chinese Medicine
Outcome results
None listed