Mechanism research on the changes in cervical tissue function and its impact on cordiality after focused ultrasound treatment for cervical lesions

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400081116

Enrollment

Unknown

Registered

2024-02-22

Start date

2024-03-01

Completion date

Unknown

Last updated

2024-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pre-cancerous cervical lesions, human papillomavirus infection

Interventions

Focused Ultrasound Group:Focused Ultrasound Therapy Group

Control subjects(Normal population group):The normal population group was defined as those with normal cervical cancer screening results and whose cervix was not undergoing any treatment modality

Eligibility

Sex/Gender

Female

Age

20 Years to 44 Years

Inclusion criteria

Inclusion criteria: (1) Women aged 20-44 years with combined cervical liquid-based cytology and HPV-DNA confirmation of HR-HPV infection with cytological results of NILM/ASCUS/LSIL/HISL HR-HPV infection with cytological findings of NILM/ASCUS/LSIL/HISL; (2) Colposcopic squamous-column junction and lesions were visible, colposcopic cervical biopsy, and pathological diagnosis of histological HSIL. (3) Non-pregnant, lactating women; (4) No antiviral treatment within three months prior to enrolment; (5) Informed consent and availability to complete follow-up visits.

Exclusion criteria

Exclusion criteria: (1) Incomplete visualisation of the transformation zone by colposcopy (2) Cytological or colposcopic examination and histological HISL (CINII/CINIII), suspicious for invasive carcinoma or glandular lesions (3) Acute inflammatory phase of the genital tract (4) STD, acquired immunodeficiency syndrome (ADS) (5) Severe cardiopulmonary and coagulation disorders. (6) Those who do not accept follow-up visits. (7) Do not agree with the treatment plan. (8) Cognitive dysfunction (9)Sexual life dysfunction (11)History of cervical physiotherapy and cervical surgery in the last 3 months

Design outcomes

Primary

Measure	Time frame
Ultrasound elasticity parameters of the cervix;Ultrasound blood flow parameters of the uterine cervix;Two-dimensional ultrasound parameters of the cervix;Oxidative stress in the microenvironment of cervical tissue;Metabolomics indicators of cervical tissue;	—

Secondary

Measure	Time frame
Histopathological findings of the cervix;human papillomavirus (HPV) ;	—

Countries

China

Contacts

Public ContactZhou Honggui

Affiliated Hospital of North Sichuan Medical College

zhy00817@163.com+86 195 5887 3342

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026