Postoperative chronic pain
Conditions
Interventions
opioid-based group:sufentanil
opioid-free group:esketamine and dexmedetomidine
Sponsors
Department of Anesthesiology, First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age =18 years old; American classification of anesthesiologists (ASA) grades I-III; patients who plan to undergo thoracoscopic lung resection and will be sent to inpatient ward; clearly understand the experiment process and participate voluntarily, sign the informed consent
Exclusion criteria
Exclusion criteria: Exclusion criteria included BMI=35 kg/m2, have narcotic drugs allergy and contraindications with esketamine, sick sinus syndrome, heart rate (HR) <50 beats min-1, second-degree or greater atrioventricular block without a pacemaker, left ventricular ejection fraction <40%, coronary heart disease, myocardial infarction, liver or renal dysfunction, Parkinson’s disease, Alzheimer’s disease, seizures, epilepsy, preoperative use of sedative-hypnotic drugs, chronic pain (defined as pain that persists or recurs for more than 3 months), preoperative use of analgesics, and inability to communicate effectively or refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of chronic pain 3 months after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS(rest, coughing);incidence of pain 1month, 3 months and 6 months after surgery;analgesic drug consumption;Length of PACU stay;incidence of postoperative nausea and vomiting;Length of postoperative hospital stay;headache, dizzine, hallucination, nightmare;quality of recovery(QoR-15); | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University
Outcome results
None listed