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The clinical and mechanism study of Tongdu Tiaoshen acupuncture on HPA-GABA-IL pathway involved in sleep regulation of MHD patients

The clinical and mechanism study of Tongdu Tiaoshen acupuncture on HPA-GABA-IL pathway involved in sleep regulation of MHD patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400081093
Enrollment
Unknown
Registered
2024-02-22
Start date
2024-03-01
Completion date
Unknown
Last updated
2024-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insomnia

Interventions

Control group:Control group took esazolam tablet 1 mg every night to improve night sleep, 3 weeks as a course of treatment, 3 weekends to observe the effect
Treatment group:Patients in the treatment group were treated with acupuncture. Tongdu TiaoShen method was used for acupuncture therapy. The main points were Baihui(GV20), Shenting(GV24), Shuigou(GV26)
Phlegm-heat internal disturbance plus Fenglong(ST40), Neiting(ST44)
Heart and spleen deficiency plus Xinshu(BL15), Pishu(BL20)
Heart and kidney imbalance add Xinshu(BL15), Shenshu(BL23)
Heart-gallbladder qi deficiency add Xinshu(BL15), Danshu(BL19)
incoordination between spleen and stomach Gongsun(SP4), Zusanli(ST36). Keep the needle for 40 minutes after the above points are acupunctured, and perform the needle once at 20 minutes. One hour aft

Sponsors

Sir Run Run Hospital of Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? The underlying disease was chronic nephritis and chronic kidney disease stage 5. Intra-arterial venous fistula was treated with MHD, continuous dialysis with high-efficiency dialyzer ?8 hours per week, continuous dialysis time ?3 months; ? Age =18 years and < 80 years. ? There are different degrees of sleep disorders; ? The patient has clear consciousness, voluntary participation, and good cooperation.

Exclusion criteria

Exclusion criteria: ? Patients with cerebrovascular diseases, combined with cognitive dysfunction, consciousness disorders, serious cardiopulmonary diseases, malignant tumors, etc.; ? Patients with severe sleep disorders or taking sleep AIDS before dialysis; The dialysis evaluation is not up to standard, the dialysis is irregular or insufficient; ? Poor compliance, withdrawal of treatment or change of dialysis center; ? Acute and chronic infections in the past 3 months; ? Patients with a history of kidney transplantation.

Design outcomes

Primary

MeasureTime frame
Pittsburgh Sleep Quality IndexI scale;?- aminobutyric acid;cortisol;Interleukin-1;

Secondary

MeasureTime frame
Kidney Disease Quality of Life Short FormF scale;triglyceride;serum albumin;Serum phosphorus;Serum Calcium;Total cholesterol;Hemoglobin;Serum parathyroid hormone;

Countries

China

Contacts

Public ContactHu Yun/Li Wen-wen

Sir Run Run Hospital of Nanjing Medical University

huyun8006@163.com+86 177 6173 9869

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026