Perioperative myocardial injury
Conditions
Interventions
Esketamine group:Esketamine
Dexmedetomidine group:Dexmedetomidine
Control group:Normal saline
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Age = 60 years old, male or female; 2) Undergoing major non-cardiac surgery, with an estimated surgical time = 2 hours and planned ICU admission after operation; 3) Have a clear understanding of the experimental process and voluntarily participate, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Sick sinus syndrome, second degree or higher atrioventricular block without a pacemaker, severe cardiac insufficiency (LVEF < 30%), severe liver insufficiency (Chil-Pugh C), and renal failure; 2) Patients with poor or untreated hypertension control (At rest, SBP greater than 180 mmHg and/or DBP greater than 100 mmHg ); 3) Unstable angina, increased intracranial pressure, intracranial aneurysms; 4) Hypersensitivity to esketamine or dexmedetomidine;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of MINS after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative elevation of cTnI;Other postoperative myocardial enzyme spectrum indicators;Quality of postoperative recovery;NRS pain score at rest and during activity at 24 and 48 hours after surgery;Complications and adverse events;Postoperative hospital stay;Postoperative 30-day mortality;Postoperative sleep quality; | — |
Countries
China
Contacts
Public ContactPeng Ke
Department of Anesthesiology, The First Affiliated Hospital of Soochow University
Outcome results
None listed