Liver failure
Conditions
Interventions
Intervention group:1000ml amber gel injection was used to pre-flush the DPMAS extracorporeal circulation pipeline, and the blood pressure was measured by a wall-mounted multifunctional monitor in the
Control group:1000ml normal saline was used to pre-flush the DPMAS extracorporeal circulation pipeline, blood pressure was measured by a wall-mounted multi-functional monitor in the ICU. The blood pr
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ?Patients with liver failure admitted to West China Hospital of Sichuan University meet the indications for the treatment of artificial liver prescribed in the Expert Consensus on the Clinical Application of artificial liver Blood Purification Technology (2022 edition), that is, "patients with pre-liver failure, early, middle and late liver failure caused by various reasons; Patients with end-stage liver disease waiting for liver source before liver transplantation, rejection after liver transplantation, and non-functional liver transplantation; Patients with severe cholestatic liver disease and severe hyperbilirubinemia caused by various causes; Other diseases such as sepsis with severe liver injury or multiple organ dysfunction syndrome, acute poisoning, etc. "? Patients with stable hemodynamics before DPMAS treatment (blood pressure > 90/60mmHg); ? The patient agrees and voluntarily signs the informed consent; ?Age =18 years old
Exclusion criteria
Exclusion criteria: ? Mental illness or other reasons can not cooperate with treatment; ? Female pregnancy test positive (pregnant women); ? Patients who have participated in other studies; ? Patients receiving other artificial liver treatment regimens; ? People with a history of allergy to succinyl gelatin injection, consumables used, blood products or drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number and incidence of hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events: allergic reactions, arrhythmia, bleeding, number of rescue cases, adjustment of vasopressor medication, etc; | — |
Countries
China
Contacts
Public ContactLin Li
West China Hospital of Sichuan University
Outcome results
None listed