intrapulmonary shunt
Conditions
Interventions
Low dose esketamine group(E1):Esketamine 0.25mg/kg was intravenously injected during induction, and 0.125mg/kg/h was continuously infused after induction
High dose esketamine group(E2):Esketamine 0.5mg/kg was intravenously injected during induction, and 0.25mg/kg/h was continuously infused after induction
control group(C):Give an equal amount of physiological saline
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. ASA I ~ III grade; 2. Selective video-assisted thoracoscopic pulmonary resection under general anesthesia was performed; 3. age 18-70 years; 4. Informed consent and willing to follow up; 5.18 = BMI = 30
Exclusion criteria
Exclusion criteria: 1. patients who are allergic to any drug in the test; 2. patients at risk of increased intracranial pressure; 3. patients with poorly controlled or untreated hypertension (resting systolic / diastolic blood pressure more than 180 / 100mmhg); 4. patients with hyperthyroidism and poor control; 5. severe cardiopulmonary disease and liver and kidney dysfunction; 6. those with a history of mental illness and drug abuse; 7. refuse to participate in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intrapulmonary shunt; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation Index;heart rate;mean arterial pressure;Oxygen Saturation; | — |
Countries
China
Contacts
Public ContactGao Jin
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed