Sleep disorder
Conditions
Interventions
Esketamine group:During the surgery, 8ml of mixed solution (formula: 7.5mg/ml ropivacaine+0.5 mg/mL of Esketamine) was injected into the Epidural. After the surgery, an epidural analgesia pump was adm
Control group :During the surgery, 8ml of mixed solution (formula: 7.5mg/ml ropivacaine+the same volume of 0.9% normal saline) was injected into the Epidural. After the surgery, an epidural analgesia
Sponsors
Women's Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Full-term pregnancy aged 20-45 years old, ASA II Level; Planned elective cesarean surgery under epidural anesthesia; Sign an informed consent form.
Exclusion criteria
Exclusion criteria: Having a clear history of mental illness (depression, schizophrenia, etc.) or sleep disorders (such as insomnia, sleep apnea, etc.) before pregnancy, or taking analgesics, sedatives, antidepressants, etc;Cognitive or communication impairment; Preoperative having serious pregnancy complications (such as severe preeclampsia, placental implantation, HELLP syndrome, placenta previa, placental abruption), combined with severe organ dysfunction or endocrine disorders in the heart, liver, and kidneys, or ASA = III level; Contraindications of Esketamine (such as hypertension, tachycardia, allergies to Esketamine and its components, etc.); Patients refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disorders on the third day after postpartum; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS sleep score on the 7th day after cesarean surgery;NRS sleep score on the 14th day after cesarean surgery;PSQI score 42 days after surgery;ISI score 42 days after surgery;SAS score 42 days after surgery;EPDS score 42 days after surgery;Postpartum breastfeeding start time;Postpartum hospitalization days;Apgar scores at 1 minutes;Apgar scores at 5 minutes;Apgar scores at 10 minutes;Adverse reactions of 72 hours after surgery; | — |
Countries
China
Contacts
Public ContactLili Xu
Women's Hospital School of Medicine Zhejiang University
Outcome results
None listed