Large cryptic varices
Conditions
Interventions
RM group:no
PO group:no
Sponsors
Zhongshan Hospital(Xiamen), Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Patients undergoing elective large saphenous vein surgery; ? Age is 18~65 years old, and gender is not limited; ? Body mass index (BMI): 18 ~ 28 kg/m2; ? American Association of Anesthesiologists' Classification (ASA): Grade I to II; ? The large saphenous vein operation lasts within 3h; ? The drug used is remazolam or propofol; The subjects voluntarily participated in the trial and signed the informed consent form for this trial.
Exclusion criteria
Exclusion criteria: ? The subject explicitly refused to participate in the study; ? Allergic to opioids, benzodiazepines, propofol, flumazenil, or naloxone drug excipients; ? Use ß blockers, anxiolytics and antidepressants; ? Suspected abuse of narcotic analgesics or sedatives, and alcoholics; ? Electrocardiogram suggests: heart rate 100 times / min or severe arrhythmia; ? History of acute respiratory infection within 2 weeks; ? Have a history of serious heart, brain, lung, liver, kidney or metabolic diseases, have neuromuscular system diseases (such as myasthenia gravis), mental diseases; ? Systolic blood pressure> 180 mmHg and (or) diastolic blood pressure> 110 mmHg in patients with preoperative hypertension, or <90 / 60 mmHg in patients with hypotension; ? History of thyroid or neck surgery; ? Previous history of abnormal surgical anesthesia recovery; ? To dict those who may or have difficult airway, such as modified horse grade-grade; ? Pregnancy or lactating women and patients with birth planning within 3 months (including men); ? Other subjects considered unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient's picture recognition and recall before and after drug administration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia awakening time;The amount of the opioids used;The incidence of the observed postoperative adverse effects; | — |
Countries
china
Contacts
Public ContactYuejiao Song
Zhongshan Hospital(Xiamen), Fudan University
Outcome results
None listed