Knee cartilage injury repair
Conditions
Interventions
experimental:Intraoperative implantation of experimental group medical device "cartilage repair material"
control:Adopt "micro fracture surgery" for treatment
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Gender is not limited, 18-60 years old, in good physical condition, able to tolerate surgery; 2) According to the damage diagnosis standard, Outerbridge is graded III and IV cartilage injury; 3) MRI evaluates the patient's large area (1-8cm²) of cartilage defects; 4) No severe joint degeneration and extraarticular deformity; 5) Informed consent: The subject must have the ability to understand and voluntarily sign written informed consent and follow the research plan and visit process;
Exclusion criteria
Exclusion criteria: 1) If the knee osteoarthritis is more than three stages, and the angle of valgus and valgus exceeds 5 degrees; 2) MRI indicates severe lower cartilage injury, combined with severe meniscus injury on the same side, and all meniscus needs to be removed; 3) Allergic constitution, such as a previous medical or family history of autoimmune diseases; 4) Those who have received bone marrow mesenchymal stem cell transplantation for cartilage defects in the affected side knee joint within 12 months before surgery, or other cartilage regeneration surgery; 5) Knee cartilage injury is caused by joint fracture, infection, tumor and immune diseases. 6) People infected with viruses or microorganisms; 7) Knee joint tumors, rheumatism, rheumatoids, tuberculosis, suppuration and complications affect joint structure; 8) Secondary knee arthritis with psoriasis and metabolic osteopathy; 9) Those who often use sedatives, sleeping pills, tranquillizers or other addictive drugs; 10) Combined with uncontrollable hypertension (drug-controlled hypertension >140mmHg, low blood pressure >100mmHg), diabetes (Used by drugs to control fasting blood glucose still >8.0mmol/L), liver and kidney function abnormalities (i.e. ALT, AST > 2.5 times normal value; creatinine > normal value 2 times); uric acid > 1.5 times normal value; 11) Those who cannot receive long-term rehabilitation training after surgery; 12) Women during family planning, breastfeeding and pregnancy within 12 months; 13) Special believers, from cattle sources; 14) Patients with body mass index BMI32; 15) Those deemed unsuitable by the researchers;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At 12 months post surgery, MOCART score was performed through magnetic resonance imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lysholm Knee Function Score;Tegner Knee Motion Level Score;IKDC score;VAS pain score;Operational satisfaction; | — |
Countries
China
Contacts
Public ContactJianquan Wang
Department of Sports Medicine, Peking University Third Hospital
Outcome results
None listed