acute nonvariceal upper gastrointestinal bleeding combined with coronary artery disease
Conditions
Interventions
Conventional treatment group:combination therapy using epinephrine injection plus hemoclip and thrombin spray
experimental group:conventional treatment combined with spraying of Histoacryl glue
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: ? Patients = 18 years old; ?Patients was diagnosed with CAD (including acute coronary syndrome, post-stenting, post-coronary artery bypass grafting, stable ischemic heart disease treated with medication only) and received anti-platelet therapy before bleeding; ?Patients with clinical evidence of bleeding (such as hematemesis, melena, hematochezia, nasogastric tube aspirate with gross blood or coffee ground material); ?Active bleeding endoscopic stigmata (spurting or oozing bleeding or with a non- bleeding visible vessel ); ?Agree to accept the study protocol; ?Voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: ? Variceal upper gastrointestinal bleeding; ? Severe coagulation disorders caused by other causes; ? Contraindications for endoscopy (such as poor general condition, severe respiratory diseases, severe circulatory diseases, neck or spine abnormalities, etc); ? Participate in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A composite of persistent bleeding, rebleeding within 7 days, or received other hemostatic treatment (e.g., transcatheter arterial embolization, surgery); | — |
Secondary
| Measure | Time frame |
|---|---|
| Units of transfusion ;Death; | — |
Countries
China
Contacts
Public ContactJie Zhang
Beijing Anzhen Hospital,Capital Medical University
Outcome results
None listed