connective tissue disease associated interstitial lung disease
Conditions
Interventions
Gold Standard:High Resolution Computed Tomography
Index test:Lung ultrasound examination
Sponsors
The First Affiliated Hospital, the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. age 18~75 years old (including both ends); 2. Patients with systemic lupus erythematosus meet the 2012 EULAR/ACR classification criteria; 3. Patients with Sjogren's syndrome meet the 2016 EULAR/ACR classification criteria; 4. Patients with systemic scleroderma meet the 2013 EULAR/ACR classification criteria; 5. Patients with rheumatoid arthritis meet the 2010 EULAR/ACR classification standards; 6. Patients with polymyositis/dermatomyositis meet the 2017 EULAR/ACR classification criteria; 7. Other rare connective tissue diseases meet the respective EULAR/ACR classification standards; 8. the urine pregnancy test of women of childbearing age must be negative, and during the study, fertile women and men must voluntarily use recognized effective contraceptive measures; 9. informed consent, voluntary participation.
Exclusion criteria
Exclusion criteria: 1. Patients in the acute exacerbation period of interstitial lung disease must use large flow oxygen or ventilators; 2. Other lung lesions other than interstitial lung disease, such as: Patients with moderate to severe pulmonary hypertension requiring special treatment: patients with other serious lung disease clinical manifestations, such as lung masses or active lung infections; Lung tissue biopsy, alveolar lavage, or HRCT suggest other severe lung disease; 3. Patients with serious diseases of the heart, liver, kidney and other important organs, blood and endocrine system or serious malignant tumors, and the researchers believe that it may bring unacceptable risks to the patients participating in this study; 4. Patients with severe lung infection; 5. Interstitial lung diseases caused by drug toxicity, occupational, environmental, and radiation damage, such as pneumoconiosis, drugs such as bleomycin, immunosuppressants, etc.; 6. Pregnant and lactating women, or those of childbearing age who cannot guarantee effective contraception; 7. have serious mental illness (schizophrenia, depression, etc.); 8. Patients with incomplete medical records or unable to fully participate in the research process; 9. Other reasons why the researcher considers it inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung ultrasound;ntraclass Correlation Coefficient,ICC;ROC curve; | — |
Countries
China
Contacts
Public ContactDing Jin
The First Affiliated Hospital, the Air Force Medical University
Outcome results
None listed