Effect of epidural infusion rate on analgesic quality of parturient labor when using epidural puncture (DPE) combined with procedural intermittent epidural extrapolation (PIEB)

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400080904

Enrollment

Unknown

Registered

2024-02-18

Start date

2024-03-01

Completion date

Unknown

Last updated

2024-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epidural labor analgesia

Interventions

0.075% Ropivacaine +0.2µg/ml fentanyl PIEB(300mL/h) group:PIEB(epidural infusion rate 300mL/h)

0.075% Ropivacaine +0.2µg/ml fentanyl DPE+PIEB(100mL/h) group:DPE+PIEB(epidural infusion rate 100mL/h)

0.075% Ropivacaine +0.2µg/ml fentanyl DPE+PIEB(300mL/h) group:DPE+PIEB(epidural infusion rate 300mL/h)

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) women between the ages of 18 and 40; (2) ASA Level 2; (3) 37-42 weeks of gestation; (4) Cervical dilation 5(0= no pain, 10= most pain).

Exclusion criteria

Exclusion criteria: (1) intraspinal anesthesia contraindications; (2) Allergic to local anesthetics or fentanyl; (3) morbid obesity; (4) known fetal malformations; (5) Obstetric complications such as gestational hypertension, pre-eclampsia, or gestational or gestational diabetes; (6) refuse to sign the informed consent; (7) Other conditions: history of cesarean section, long-term use of sedatives or analgesics.

Design outcomes

Primary

Measure	Time frame
Proportion of women in each group who had pain outbreaks requiring PCEA or manual intervention by an anesthesiologist.;	—

Secondary

Measure	Time frame
Consumption of ropivacaine per hour.;Sufficient onset time for analgesia.;Analgesic pump drug use: first PCEA time, number of PCEA compressions, PCEA request/actual compressions ratio.;NRS pain score (NRS pain score before analgesia, 30min, second stage of labor: uterine opening, fetal delivery).;Maternal basic information: age, weight, height, pregnancy, number of pregnancies, uterine opening before labor analgesia, oxytocin use, first stage of labor time, second stage of labor time.;Methods of delivery: natural delivery, forceps delivery, caesarean section transfer cases.;Side effects: nausea, vomiting, itching, chills, hypotension, respiratory depression, excessive sedation, etc.;Neonatal condition: Apgar score 1min 5min.;	—

Measure

Time frame

Consumption of ropivacaine per hour.;Sufficient onset time for analgesia.;Analgesic pump drug use: first PCEA time, number of PCEA compressions, PCEA request/actual compressions ratio.;NRS pain score (NRS pain score before analgesia, 30min, second stage of labor: uterine opening, fetal delivery).;Maternal basic information: age, weight, height, pregnancy, number of pregnancies, uterine opening before labor analgesia, oxytocin use, first stage of labor time, second stage of labor time.;Methods of delivery: natural delivery, forceps delivery, caesarean section transfer cases.;Side effects: nausea, vomiting, itching, chills, hypotension, respiratory depression, excessive sedation, etc.;Neonatal condition: Apgar score 1min 5min.;

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Countries

China

Contacts

Public ContactZhong Mei

Zhejiang Xiaoshan Hospital

meizhong@zju.edu.cn+86 189 6997 9723

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026