Chronic sinusitis
Conditions
Interventions
Group A:The nasal cavity was rinsed twice a day with normal saline through nasal nebulization, combined with nasal hormone spray every night, 1 spray per side. The treatment cycle is 3 months, nasal i
Group B:Rinse the nasal cavity twice a day with 0.5mg budesonide suspension mixed with normal saline transnasal nebulization for two consecutive weeks, and then rinse the nasal cavity twice a day with
Group C:Rinse the nasal cavity twice a day with 1.0 mg budesonide suspension mixed with normal saline transnasal nebulization for two consecutive weeks, and then rinse the nasal cavity twice a day wit
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Chronic sinusitis according to the diagnostic criteria of "Chinese Guidelines for the Diagnosis and Treatment of Chronic Sinusitis (2018)" A. Symptoms: Main symptoms: nasal congestion, sticky or purulent nasal discharge. Secondary symptoms: Head and facial pain, loss of smell. The diagnosis is based on two or more related symptoms mentioned above, and one of the main symptoms must be present. B. Sinus CT evaluation Lund-Mackay score = 2 C. Nasal endoscopy that meets guideline diagnostic criteria D. Age: 6 years old = age = 18 years old, no limit to male or female Ps: The diagnosis of CRS in children should be based on symptoms and nasal endoscopy
Exclusion criteria
Exclusion criteria: Exclusion Criteria: a) Sinus surgery within the last year; b) aspirin tolerance; c) cystic fibrosis; d) pregnancy; e) Diabetes mellitus: f) severe/unstable intercurrent illness or any mental illness; g) Odontogenic sinusitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal microbes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lund-Mackay score;visual analogue scale;Sino-Nasal Outcome Test;serum cortisol;serum IgE;Eosinophil count;sIgA;Markers of inflammation; | — |
Countries
China
Contacts
Public ContactYong Li
Hangzhou First People's Hospital
Outcome results
None listed