Community-acquired pneumonia in children
Conditions
Interventions
Model solution group:Intravenous infusion of azithromycin, 15 mg/kg on day 1 and 10 mg/kg on day 2-5
Conventional solution group:Intravenous infusion of azithromycin, 10 mg/kg daily for 5 days
Sponsors
Baoding Children's Hospital
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: 1) Age 1 month to 18 years; 2) The CAP diagnostic criteria; 3) Suitable for intravenous AZM treatment and the duration of AZM treatment is estimated at least five days; 4) ICF signed by the guardians of the participants. Children aged of 8-18 years old must sign the ICF personally.
Exclusion criteria
Exclusion criteria: 1) Hypersensitivity to AZM; 2) Incomplete AZM dose information or clinical information; 3) Hospital-acquired pneumonia (HAP, pneumonia that occurred 48 hours after admission with no diagnosis of pneumonia before admission) or ventilator-associated pneumonia (VAP, pneumonia that occurred 48 to 72 hours after mechanical ventilation); 4) Multiple episodes of CAP in the same patient; 5) Children with any comorbidity of meningitis, tuberculosis, immunosuppression, acute malnutrition or symptoms indicating chronic illness; 6) Corrected QT interval (QTc) is greater than 440 ms on electrocardiogram (ECG); 7) The patient participating in other clinical trials or receiving other antibiotics with a similar antibacterial spectrum to AZM (including third generation cephalosporins, carbapenems, and so on); 8) Having other factors that researchers believe are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood drug concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function;Renal function;White blood cells;C-reactive protein; | — |
Countries
China
Contacts
Public ContactAdong Shen; Bi Jing
Baoding Children's Hospital
Outcome results
None listed