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Canceled by the investigator Subanesthetic doses of esketamine for the prevention of catheter-related bladder discomfort in elderly patients recovering from general anesthesia: a prospective, randomized, controlled study

Subanesthetic doses of esketamine for the prevention of catheter-related bladder discomfort in elderly patients recovering from general anesthesia: a prospective, randomized, controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400080885
Enrollment
Unknown
Registered
2024-02-15
Start date
2024-02-16
Completion date
Unknown
Last updated
2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

catheter-related bladder discomfort (CRBD)

Interventions

Esketamine group:After induction of anesthesia, the patient was given esketamine with a load of 0.2mg/kg and pumped with a load of 10min. Thereafter, the intraoperative maintenance dose was 0.12mg·kg-
Control group:An equal volume of 0.9% sodium chloride injection was given.

Sponsors

Fuyang City People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
60 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Male patients with catheterization after pseudo-general anesthesia, ASA I-II; 2. Age 60 to 75 years old, BMI 18.5-27.9 kg/m2; 3. The patient has normal communication ability and no cognitive dysfunction; 4. Patients or family members are informed and sign consent forms.

Exclusion criteria

Exclusion criteria: 1. Patients with bladder dysfunction, including bladder outflow tract obstruction, neurogenic bladder dysfunction, and bladder overactivity syndrome (urination frequency higher than 8 times /24h or 3 times/night); 2. Abnormal urethral anatomy; 3. Patients with increased intracranial pressure or central nervous system injury; 4. Patients who have or have had a history of serious mental disorders; 5. Combined with glaucoma; 6. Patients with a history of narcotic analgesic drugs or alcohol dependence.

Design outcomes

Primary

MeasureTime frame
Incidence of CRBD 0 hours after surgery;Incidence of CRBD 1 hour and 6 hours after surgery;CRBD severity at each time point after surgery;

Secondary

MeasureTime frame
VAS scores of patients at each time point after surgery;Ramsay score at each time point after operation;Incidence of postoperative associated adverse reactions;

Countries

China

Contacts

Public ContactLi Lei

Fuyang City People's Hospital

lilei_mzk@163.com+86 188 5686 6070

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026