melasma
Conditions
Interventions
experimental group: intradermal injection of botulinum toxin type A
Sponsors
Dermatology Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients who meet all of the following criteria may be considered for inclusion: 1) Symmetrical stable melasma, defined as bilateral melasma with similar appearance and position. (During non-inflammatory erythema) 2) Patients aged 18-50 years 3) Agreed to follow the experimental treatment plan and visit plan, voluntarily enrolled in the group, and signed the informed consent in person
Exclusion criteria
Exclusion criteria: Patients who meet any of the following criteria are not eligible for admission: 1) Medical history/surgical history of any uncontrolled clinical systemic diseases that are serious or may affect treatment and effectiveness evaluation, such as circulatory system, nervous system, blood system, immune system, mental system diseases, etc.; 2) Significant changes in body weight during treatment (up and down 5%); 3) Receive other facial rejuvenation treatments during treatment; 4) Unprotected sun exposure during treatment; 5) Have a history of malignant tumors; 6) The patient has uncontrolled hypertension (blood pressure above 140 mmHg/90 mmHg), or a history of hypotension (blood pressure below 90 mmHg/60 mmHg); 7) Had undergone major surgery within 3 months prior to screening, or planned to undergo major surgery during the trial; 8) Participants who have participated or are participating in clinical trials of other interventional drugs or medical devices within 3 months prior to screening; 9) Received other photoelectric therapy 3 months before screening, oral tranexamic acid, glutathione, oral contraceptives, isotretinoin, minocycline and other drugs that affect melasma or have photosensitive properties 3 months before screening; 10) The investigator believes that the subjects have other conditions that may affect their compliance or are not suitable for participating in the study; 11) Prior to screening, there was a history of substance abuse, drug use or alcohol dependence
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified melasma area severity index; | — |
Secondary
| Measure | Time frame |
|---|---|
| melasma area and severity index;Melanin index;VAS; | — |
Countries
China
Contacts
Public Contactliuzhengfeng
Dermatology Hospital of Southern Medical University
Outcome results
None listed