postoperative delirium
Conditions
Interventions
Esketamine group (Group E):Esketamine
Cyclophenol group(Group C):Cyclophenol
Remazolam group(Group R):Remazolam
Dextrmetomidine group (Group D):Dextrmetomidine
control group:Normal saline
Propofol group:Propofol
Sponsors
Department of Anesthesiology, Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Age = 60 years old; 2.ASA I - III 3.Accept joint replacement surgery under intraspinal anesthesia, and agree to use PCIA after surgery 4.Sign the informed consent voluntarily
Exclusion criteria
Exclusion criteria: 1.Past cognitive impairment (dementia, cognitive impairment, mental illness or mental disorder) 2.Complex injuries: multiple fractures, chest and abdomen, pelvic and sacral trauma, head trauma, etc 3.Contraindications to intraspinal puncture (coagulation dysfunction, thrombocytopenia, intraspinal space occupation, puncture site infection, etc.) 4.Have a history of acute myocardial infarction or stroke within 3 months 5.Patients with severe liver dysfunction (Child-Pugh C) or renal failure 6.Contraindications to ketamine, such as malignant hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within 3 days after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute pain score within 3 days after operation;Other related complications and results: nightmares, hallucinations, hypotension, bradycardia;Length of stay;Total cost of hospitalization and anesthesia;Comfort and satisfaction of anesthesia; | — |
Countries
China
Contacts
Public ContactHongfei Zhang
Zhujiang Hospital of Southern Medical University
Outcome results
None listed