Critical illness
Conditions
Interventions
Experimental group:Receive an additional daily 3 g of HMB + 60 g of protein supplementation for 90 days
Control group:No additional nutritional support is provided
Sponsors
Jinling Hospital Affiliated to Nanjing University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Obtain informed consent 2. Age = 18 years old 3. It is expected to be out of the ICU within 24 hours 4. Mechanical ventilation for at least 48 hours during the ICU stay 5. Have been admitted to ICU for at least 8 days, but not more than 28 days
Exclusion criteria
Exclusion criteria: 1. Patients who are expected to die or stop life support treatment within 48 hours after being discharged from the ICU 2. Patients who are expected to need to be readmitted to the ICU within 1 week after being discharged from the ICU 3. Severe liver failure (Child-Pugh grade C) at the time of discharge from the ICU 4. Chronic kidney disease (creatinine clearance rate< 40mL/min) 5. Patients who are pregnant or breastfeeding 6. Unable to walk independently before admission to the ICU (if you can walk independently with a walking aid, you can be included) 7. There are contraindications to the use of protein supplements or HMB products (e.g., severe renal insufficiency requiring regular hemodialysis, allergy to whey protein, etc.) 8. Patients with known cognitive dysfunction, lower limb injury, systemic neuromuscular disease, and cranial or spinal problems and other problems that affect the evaluation of study results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6 minutes walking distance ; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood urea nitrogen;Serum creatinine;Prealbumin;Albumin;C-reaction protein;lymphocyte;Mortality;Proportion of ICU readmission;Days of non-hospitalization and survival;Readmission hospital rate;gait reconstruction data analysis;Hand grip strength measurement;Barthel Index;Clinical Frailty Scale;Nutritional support;Subjective globe assessment;EuroQol five dimensions five-level questionnaire;Body composition analysis; | — |
Countries
China
Contacts
Public ContactLi Weiqin
Jinling Hospital Affiliated to Nanjing University School of Medicine
Outcome results
None listed