Infertility (with decreased ovarian reserve)
Conditions
Interventions
Intervention group:Acupuncture+ Microstimulation techniques to induce ovulation
Control group:Microstimulation techniques to induce ovulation
Sponsors
The Third Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: ? Fulfill the diagnostic criteria for diminished ovarian reserve (DOR) and infertility, and undergo assisted reproductive technology (ART) treatment. ? Married women aged between 20 and 40 years. ? It is recommended to implement the excretion promotion program specified in this research. ? Prior to hysteroscopy or fallopian tube examination, ensure that the uterine cavity exhibits normal shape, If there are endometrial polyps or mild uterine adhesions, they can be cured through surgery, medication, and other means. ? Maintain a normal sexual life and have a healthy spouse without any organic reproductive system diseases. Additionally, ensure that semen routine analysis yields predominantly normal results. ? Confirm that both partners possess normal bilateral chromosome karyotypes and are free from genetic diseases. ? Voluntarily participate in this clinical study, continuously treat for 3 menstrual cycles, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: ? Premature ovarian failure (POF) patients, specifically those with two follicle-stimulating hormone (FSH) measurements taken on the 2nd to 4th day of the menstrual cycle, at least 4 weeks apart, showing levels exceeding 40U/L, or those with other causes of infertility such as thin endometrium and other uterine factors; ? In addition to the treatment measures outlined in this study, some patients also received additional treatment measures, while others did not adhere to the prescribed medication or acupuncture protocols, resulting in an inability to assess the efficacy and hindering the observation and judgment due to incomplete data. ? Patients presenting with endocrine disorders, including adrenal, thyroid, and prolactin dysfunction; ? Concurrently afflicted with severe underlying conditions such as cardiovascular and cerebrovascular diseases, liver and kidney disorders, hematopoietic system abnormalities, and serious psychiatric illnesses; ? Oversensitivity to electrical stimulation; ? Refuse to sign informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The clinical pregnancy rate;Serum Anti Mullerian Hormone, AMH;Follicle Stimulating Hormone, FSH;Metabolomics of follicular fluid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sinus follicle count;The oocyte count was obtained;The numerical count of embryos;The rate of implantation for the initial transplantation;The incidence of miscarriage following the initial transplantation;The prevalence of diminished ovarian response;The utilization of gonadotropins, encompassing factors such as the quantity of initiation, overall duration of usage, and cumulative dosage;The frequency of oocyte retrieval from the ovaries;The frequency of embryo transfer; | — |
Countries
China
Contacts
Public ContactChen Lifang
The Third Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed