Children requiring painless gastroscopy
Conditions
Interventions
Part 2:Remazolam and fentanyl:Intravenous ED95 doses of remazolam and fentanyl, Remedy: Add remazolam 0.1mg/kg each time, and do not add more than 5 times during the gastroscopy.
Part 2:Propofol and fentanyl:Intravenous propofol and fentanyl, Remedy: Add propofol 0.5mg/kg each time, during the gastroscopy, add no more than 5 times.
Part 1:Remazolam and fentanyl:Intravenous remazolam and fentanyl, Remedy: 0.5-2mg/kg (per session) of propofol for remedial sedation to complete endoscopy.
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
7 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. ASA Level I, II 2. Aged 7-12 years old 3. Meet the weight standard: Seven-year-old boys/girls 18.5kg~35.5kg/17.6kg~32.0kg Eight-year-old boys/girls 20.3kg~41.5kg/19.2kg~36.7kg Nine-year-old boys/girls 22.0kg~47.2kg/20.9kg~42.5kg Ten-year-old boys/girls 23.9kg~52.9kg/22.9kg~49.6kg Eleven-year-old boys/girls 26.2kg~59.4kg/25.7kg~56.7kg Twelve-year-old boys/girls 29.0kg~66.8kg/29.3kg~61.9kg 4. Children requiring painless gastroscopy 5. Preoperative heart, lung, liver, kidney, and other functions are basically normal
Exclusion criteria
Exclusion criteria: 1. Allergic history of fentanyl, remazolam and propofol 2. Children with airway hyperresponsiveness disease 3. Children with difficult airway 4. Participating in other studies 5. Children with upper respiratory tract infection within 1 month 6. Children with severe gastrointestinal lesions requiring special treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discharge time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of recovery;Body motion rate;Hypotension;Hypoxemia;Injection pain;Endoscopist satisfaction;Refill times; | — |
Countries
China
Contacts
Public ContactHan Lin
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed