Acute Postoperative pain
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients who meet the diagnostic criteria of unilateral knee osteoarthritis and meet the surgical indications ; 2, aged between 60 and 80 years old ; 3.All patients who signed the informed consent, were willing to accept and cooperate with the examination and treatment and postoperative follow-up.
Exclusion criteria
Exclusion criteria: 1.Patients with any drug allergy or suspected allergy in the study. 2.Patients with coagulation disorders or liver disease ; or have a history of bleeding. 3.Patients with high risk of systemic infection, hip skin damage, and poor local infection control. 4.Heparin, low molecular weight heparin, etc.have been continuously used before surgery. 5.Long-term use of central and peripheral nerve analgesics, long-term use of glucocorticoids, long-term use of non-steroidal anti-inflammatory analgesics ; the history of medication in conflict with this study. 6.Severe liver and kidney dysfunction, severe cardiovascular and cerebrovascular diseases, malignant tumors and other medical history. 7.Reluctant to cooperate with this study, or patients with mental illness, other reasons can not be included in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| PGE2;Stress pain threshold test; | — |
Countries
China
Contacts
Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine