Prediabetes
Conditions
Interventions
Usual care:The usual care group comprises a single face-to-face education session, lifestyle guidance based on WeChat public accounts, and general health communication, such as posting bulletin boards
Digital-based lifestyle intervention:The digital-based lifestyle intervention group, in addition to including the content of the usual care group, also encompasses lifestyle guidance based on mobile t
Complex intervention:The complex intervention group, beyond including the elements of both the usual care group and the digital-based intervention group, also incorporates face-to-face lifestyle couns
Sponsors
Chinese Academy of Medical Sciences & Peking Union Medical College
Eligibility
Sex/Gender
All
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: ?Participants aged 25-55 years; ?Prediabetes defined as impaired fasting glucose (fasting plasma glucose 6.1–6.9mmol/L), impaired glucose tolerance (2-h plasma glucose 7.8–11.0 mmol/L during oral glucose tolerance test [OGTT]), elevated HbA1c (5.7%-6.4% [39-47 mmol/mol]) or intermediate hyperglycemia(1hPG=8.6mmol/L); ?Staff in the Daqing Oilfield Production; ?Possibility to use a computer, smartphone, or tablet with internet connection; ?Willingness to sign the written informed consent form.
Exclusion criteria
Exclusion criteria: ?Documented presence of diabetes; ?Women who were pregnant, lactating, or planning to become pregnant in the next 36 months; ?Taking medications that could alter glucose metabolism within six months; ?Persistent uncontrolled hypertension (SBP =160 mmHg or DBP =100 mmHg); ?Subjects with a total knee or hip replacement in either limb within 3 months; ?Significant CVD within 6 months (acute myocardial infarction, Class III/IV congestive heart failure defined by the New York Society of Cardiology, left ventricular ejection fraction =40% or cerebrovascular accident); ?Active cancer or less than 6 months from cancer treatment; ?Impaired liver function (including obvious clinical signs or symptoms of liver disease, acute or chronic hepatitis, ALT or AST levels =3 times the upper limit of the reference range at the screening visit); ?Renal dysfunction (eGFR <45 mL/min); ?Diseases related to glucose metabolism disorder (e.g., Cushion's syndrome); ?Participation in projects involving lifestyle modifications or other clinical trials within 30 days; ?Any other significant medical or psychological condition that could endanger the health of the participant or confound the study results if the participant was enrolled.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diabetes incidence rate;Reversion to normoglycemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting plasma glucose;2-h plasma glucose during oral glucose tolerance test;Hemoglobin A1C (HbA1c);Weight;Body Mass Index;Waist Circumference;Dietary behavior;Physical activity;Sleep quality;Tobacco and alcohol use;Knowledge of prediabetes;Psychological status;Self-efficacy;Social support;Health related life quality; | — |
Countries
China
Contacts
Public ContactRuitai Shao
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Outcome results
None listed