osteoarthritis
Conditions
Interventions
Regular dose group:Celecoxib orally 400mg/d treatment for 3 months
Low dose group:Celecoxib orally 100 mg/d treatment for 3 months
Sponsors
Xi'an Honghui Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: ? 40-90 years old, no gender limit; ? Standing anteroposterior and lateral knee joint X-rays show evidence of grade 2 (mild) or grade 3 (moderate) osteoarthritis; ? Patients and their families actively cooperate with the clinic Trial conduct and follow-up.
Exclusion criteria
Exclusion criteria: ? Knee joint infection, tumors around the knee joint, congenital diseases, etc. found before or during the operation; ? History of taking hormones in the past 3 months; ? Severe neurological or vascular diseases affecting the lower limbs; ? Rheumatoid arthritis, ankylosing arthritis, etc. Spondylitis, gouty arthritis, seronegative spondyloarthropathy, fibromyalgia, bursitis, tendinitis; ? History of trauma, surgery, or knee joint injection of corticosteroids within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum PGE2;Serum COX-2;bone marrow edema;subchondral bone remodeling; | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC pain score;Stanford Health Assessment Questionnaire (HAQ);KSS score;Knee ROM;Dependency assessment; | — |
Countries
China
Contacts
Public ContactJinwen He
Xi'an Honghui Hospital
Outcome results
None listed