Liver Diseases
Conditions
Interventions
group of "Stroke Volume Variation":Guidance of hepatic resection and fluid management based on "Stroke Volume Variation" changes
group of "Low Central Venous Pressure":Liver resection section maintains central venous pressure <or =5cmH2O, fluid resuscitation after liver resection
Sponsors
Sichuan Academy of Medical Sciences – Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: liver resection ( resection>=3 segments),age (18-75years), ASA (I-III), NYHA (I or II), Child-Pugh(A or B), Operation duration (2-4hours)
Exclusion criteria
Exclusion criteria: Severe heart disease, cardiac arrhythmia, acute upper respiratory infection, acute exacerbation of chronic non-obstructive pulmonary disease, corticosteroid infection or treatment, preoperative renal failure(GFR [eGFR] <30 ml/min/1.73 m2),liver resectionresection<3 segments)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal fatty aid binding protein;liver-fatty acid binding protein;creatinine;sodium in urine;urine osmolality;Tissue inhibitor of matrix metalloproteinase-2;insulin-like growth factor binding protein 7;N-acetyl-ß-D-glucosidase;high-sensitive Troponin T; | — |
Secondary
| Measure | Time frame |
|---|---|
| neuron-specific enolase;mean arterial pressure;heart rate;central venous pressure;cardiac index;Stroke Volume Variation;fluid infusion;blood loss;urine output;Vasoactive drug usage;30-day postoperative mortality rate; | — |
Countries
China
Contacts
Public ContactXu Guangmin
Sichuan Academy of Medical Sciences – Sichuan Provincial People's Hospital
Outcome results
None listed