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Efficacy and Safety of Hydromorphone caudal canal combined with intercostal nerve block During VATS: A Randomized Clinical Trial

Efficacy and Safety of Hydromorphone caudal canal combined with intercostal nerve block During VATS: A Randomized Clinical Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400080726
Enrollment
Unknown
Registered
2024-02-05
Start date
2024-03-01
Completion date
Unknown
Last updated
2024-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Sacral canal group (R group):Hydromorphone 1mg (diluted to 20ml with normal saline)
Control group (Group C):20ml with normal saline

Sponsors

Dongguan Tungwah hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients selected to undergo thoracoscopic lobectomy under elective general anesthesia were of all genders, aged 20-65 years, BMI 18-25 kg/m2, ASA grade I or II.

Exclusion criteria

Exclusion criteria: A history of allergy to ropivacaine, long-term use of opioids, sedatives, antidepressants, and monoamine oxidase inhibitors, a history of peptic ulcer, hypertension, coronary heart disease, central nervous system disease, or mental illness, and a history of refusal to participate in this study.

Design outcomes

Primary

MeasureTime frame
QoR-40 score;C-reactive protein, IL-6, IL-8, TNF-a, and cortisol levels;

Secondary

MeasureTime frame
Consumption of opioids;The number of analgesic pump compressions and the number of effective compressions;Rest and cough pain score (VAS);The Prince-Henry pain score;Mean arterial blood pressure and heart rate;

Countries

China

Contacts

Public ContactXueping Li

Dongguan Tungwah hospital

dhyyxueping@163.com+86 138 2728 2233

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026