Helicobacter pylori infection
Conditions
Interventions
LBTM quadruple group (control group):Lansoprazole 30mg bid+colloidal pectin bismuth 150mg tid+tetracycline 0.5 tid+metronidazole 0.4 tid. 14 days
VT dual group (test group):vonoprazan 20mg bid+tetracycline 0.5 tid. 14 days
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 18 to 80 years old, regardless of gender; 2. patients with Helicobacter pylori positive who have previously failed eradication (unlimited number of treatment times)
Exclusion criteria
Exclusion criteria: 1. Previous treatment plans for Helicobacter pylori include a combination of PPI, bismuth, tetracycline, and metronidazole; 2. Those who have used antibiotics, bismuth or PPI within 4 weeks before treatment; 3. Pregnant or lactating women; 4. Patients with other serious diseases that may affect the evaluation of this study, such as severe liver disease, heart disease, kidney disease, malignant tumors, or alcoholism; 5. Individuals who are allergic to the drugs or their components used in this study; 6. Participated in other drug studies within 3 months prior to using the investigated drug; 7. Patients are unable to express their complaints correctly, such as mental illness or severe neurosis, and cannot cooperate with the participants in this trial; 8. Other situations that the researcher deems unsuitable for participation in this experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| side effect; | — |
Countries
China
Contacts
Public ContactWen Gao
Peking University First Hospital
Outcome results
None listed