pneumonia in children
Conditions
Interventions
Experiment group 1:None
Experiment group A:1.General treatment : If intravenous rehydration is necessary, the total amount of fluid should be calculated according to 80% of the normal requirement of basal metabolism, and ser
Experiment group B:1.General treatment : If intravenous rehydration is necessary, the total amount of fluid should be calculated according to 80% of the normal requirement of basal metabolism, and ser
Sponsors
Affiliated Hospital of Changchun University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
3 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1.Changes of respiratory tract microorganisms in children with pneumonia ( 1 ) In line with the western medicine diagnostic criteria of ' Diagnosis and Treatment Standard of Community Acquired Pneumonia in Children ' ( 2019 Edition ) and ' Diagnosis and Treatment Guideline of Mycoplasma Pneumoniae Pneumonia in Children ' ( 2023 Edition ) ; ( 2 ) In line with the Chinese Medical Association 's " Guidelines for the Diagnosis and Treatment of Common Diseases in Pediatrics of Traditional Chinese Medicine · Pneumonia and Asthma " ( 2012 Edition ) TCM diagnostic criteria ; ( 3 ) Aged from 3 to 17 years old ; ( 4 ) Have not taken traditional Chinese medicine or western medicine within 1 month before inclusion ; ( 5 ) The legal guardian of the child informed consent and signed the informed consent. 2.Effect of Qingfei Decoction on respiratory microorganisms in bacterial pneumonia ( 1 ) Conform to the diagnostic criteria for bacterial pneumonia in children of Western medicine developed by the ' Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia in Children ' ( 2019 Edition ) and the previous clinical trial study of the research group ( China Clinical Trial Registry registration number : ChiCTR 1900025354 ) ; ( 2 ) In line with the Chinese Medical Association 's ' Guidelines for the Diagnosis and Treatment of Common Diseases in Pediatrics of Traditional Chinese Medicine • Pneumonia Asthma ' wind-heat stagnation lung syndrome TCM diagnostic criteria ; ( 3 ) Aged from 3 to 17 years old ; ( 4 ) Have not taken traditional Chinese medicine or western medicine within 1 month before inclusion ; ( 5 ) The legal guardian of the child informed consent and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1.Changes of respiratory tract microorganisms in children with pneumonia ( 1 ) Confirmed or suspected pneumonia caused by non-community-acquired pathogens ( e.g., ventilator-associated pneumonia, hospital-acquired pneumonia, aspiration pneumonia ) ; ( 2 ) Non-infectious causes of pulmonary infiltration ( such as pulmonary embolism, inhalation-induced chemical pneumonia, allergic pneumonia, congestive heart failure ) ; ( 3 ) pleural empyema ( excluding non-suppurative pneumonia pleural effusion ) ; ( 4 ) Including but not limited to pneumonia with bronchial asthma, bronchial foreign body ; pneumonia combined with measles, pertussis, influenza ; pneumonia combined with other severe primary lung diseases ; ( 5 ) Patients with community-acquired pneumonia who needed to be treated in ICU ; ( 6 ) Patients who used antiviral, antibiotic or traditional Chinese medicine injections within 72 hours before enrollment ; ( 7 ) Evidence of immediate life-threatening diseases, including, but not limited to, current or impending respiratory failure, acute heart failure, shock, acute liver failure, active gastrointestinal bleeding ; ( 8 ) patients with pneumonia complicated with primary other systemic diseases ; ( 9 ) those who are unable or unwilling to comply with the procedures and restrictions specified in the study. 2.Effect of Qingfei Decoction on respiratory microorganisms in bacterial pneumonia ( 1 ) Confirmed or suspected pneumonia caused by non-community-acquired pathogens ( e.g., ventilator-associated pneumonia, hospital-acquired pneumonia, aspiration pneumonia ) ; ( 2 ) Non-infectious causes of pulmonary infiltration ( such as pulmonary embolism, inhalation-induced chemical pneumonia, allergic pneumonia, congestive heart failure ) ; ( 3 ) pleural empyema ( excluding non-suppurative pneumonia pleural effusion ) ; ( 4 ) Patients who were confirmed or suspected to be infected with atypical pathogens according to epidemiological background ( MP antibody titer = 1 : 160 or IgM positive ; chlamydia pneumoniae single serum IgM titer = 1 : 16 or IgG titer = 1 : 512 ) ; virus ( such as Coxsackie virus, influenza A virus, influenza B virus, human parainfluenza virus, human respiratory syncytial virus, adenovirus IgM positive ) infection ; ( 5 ) Including but not limited to pneumonia with bronchial asthma, bronchial foreign body ; pneumonia combined with measles, pertussis, influenza ; pneumonia combined with other severe primary lung diseases ; ( 6 ) community-acquired pneumonia need to enter the ICU treatment ; ( 7 ) Patients who used antibiotics within 72 hours before enrollment ( except for single-day oral or intravenous short-acting antibiotics ; ( 8 ) Patients who were allergic to ß-lactam antibiotics and traditional Chinese medicine components used in previous studies ; ( 9 ) Evidence of immediately life-threatening diseases, including, but not limited to, current or impending respiratory failure, acute heart failure, shock, acute liver failure, active gastrointestinal bleeding ; ( 10 ) patients with pneumonia complicated with primary other systemic diseases ; ( 11 ) those who are unable or unwilling to comply with the procedures and restrictions specified in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oropharyngeal microbial metagenomic sequencing; | — |
Countries
China
Contacts
Public ContactLiping Sun
Affiliated Hospital of Changchun University of Traditional Chinese Medicine
Outcome results
None listed