Hyperbaric oxygen combined with computerized cognitive training for the treatment of post-stroke cognitive impairment: an investigation of the efficacy and mechanism

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400080685

Enrollment

Unknown

Registered

2024-02-05

Start date

2024-03-01

Completion date

Unknown

Last updated

2024-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke cognitive impairment

Interventions

Hyperbaric Oxygen Combined Cognitive Training Group:Hyperbaric Oxygen Combined Cognitive Training

hyperbaric oxygen group:hyperbaric oxygen

Cognitive Training Group:Cognitive Training

control subjects:conventional treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1: Those who are diagnosed by clinical MRI, CT, cerebral angiography and other examinations and meet the diagnostic criteria of stroke (cerebral hemorrhage, cerebral infarction, subarachnoid hemorrhage); 2: No age limit, first onset of disease and stable condition without progression. 3: Patients with mild to moderate cognitive impairment with a score of 10 < 24 on the MMSE (Measure of Mental Status Examination). 4: Patients recovering from stroke 5: All of them are hospitalized cases in the rehabilitation department of our hospital and have medical records; 6:The patients' family members agreed to the treatment and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1: Patients who are unable to cooperate with the study due to severe cognitive impairment (MMSE score =10), aphasia or other factors 2: Patients with mental retardation before the onset of the disease or other diseases causing cognitive dysfunction other than stroke, such as Parkinson's disease and Alzheimer's disease, etc. 3: Combination of serious organic lesions of internal organs or systemic infectious diseases; 4: Systolic blood pressure =160mmHg and/or diastolic blood pressure =100mmHg with heart rate =50 beats. 5: Combined with pneumothorax, severe emphysema, upper respiratory tract infection, otitis media, sinusitis and other contraindications to hyperbaric oxygen therapy.

Design outcomes

Secondary

Measure	Time frame
Simple Mental Status Examination Scale;Assessment of ability to perform activities of daily living;Lovingston Cognitive Rating;	—

Primary

Measure	Time frame
Montreal Cognitive Assessment Scale;	—

Countries

China

Contacts

Public ContactLiu Jing

Shandong Provincial Third Hospital Shandong University

1191516536@qq.com+86 151 0699 5750

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026