Safety and efficacy of intraosseous regional prophylaxis in prevention of infection in hip and knee arthroplasty

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400080681

Enrollment

Unknown

Registered

2024-02-04

Start date

2024-02-04

Completion date

Unknown

Last updated

2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hip and knee arthroplasty

Interventions

Group 1:Intramedullary injection of antibiotics

Group 2:Intravenous infusion of antibiotics

Group 3:Intravenous infusion of antibiotics

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients over 18 years old who underwent hip and knee arthroplasty 2.The subjects are fully aware of the benefits and risks of this experiment, and are willing to participate in the completion of the experiment and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.There used to be osteofascial compartment syndrome. 2.Antibiotics were used within 7 days before operation. 3.Known allergy toantibiotics. 4. There are major heart, liver and kidney diseases. 5. Patients with surgical site infection or systemic infection

Design outcomes

Primary

Measure	Time frame
Drug concentration;Inflammation index;Blood routine;Liver and kidney function;Blood clotting function;Vital signs;	—

Secondary

Measure	Time frame
Range of Motion of Joint;KSS score;satisfatory score;VAS score;Harris Score;Infusion time;	—

Countries

China

Contacts

Public ContactMing Ni

Department of Orthopedics of First Medical Center of General Hospital of PLA

niming301@163.com+86 135 8191 5896

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026